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Most doctors prescribe 500mg of Metformin (Glucophage) before eating. Part of what metformin does is make you less insulin resistant. Rinse the glass or cup with more water and drink to make sure you have taken all the medicine. Then turn the ampule upside down and slowly squeeze the soft (middle) part of the ampule to empty the contents into a glass or cup of water. To take this medication directly, slowly squeeze the soft (middle) part of the open ampule to empty the contents into the mouth o...