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What is pill esophagitis? Pill esophagitis is a serious condition that can affect both adults and children. It is caused by the accidental ingestion of certain pills, and can lead to acute inflammation of the lining of the esophagus. In some cases, pill esophagitis may be fatal. If you suspect that you or a loved one has pill esophagitis, seek medical attention as soon as possible. Treatment typically involves antibiotics and aggressive hydration. If left untreated, pill esophagitis can lea...